Sunday , March 7 2021

Scientists solve the mechanism of recall – and forget



Scientists solve the mechanism of recall - and forget
Image: Pixabay

For the first time, scientists at Scripps Research discovered a physiological mechanism in which a memory in the brain was created and then forgotten.

Scientists have studied fruit flies. They conditioned the flies to associate a specific odor with electric shock. After training, the scientists then observed that they prevented this fragrance confirming that memory was made.

He then followed the activity of neurons in the brain during the conditioning procedure. In doing so, they managed to take an internal look at the physiological foundations of memory regulation.

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Jacob Berry, the first author in post-doctoral study at the Department of Neuroscience of Scripps Research's Florida campus, said, olarak We believe that this system was created to remove the insignificant and long-lasting memories. I find it elegant that all this is done with the same neuron. Our article emphasizes exactly how to achieve this. "

For the study, scientists used imaging techniques to look at this process in more detail. When a behavioral memory deteriorated, they discovered that cellular changes in the learning process were reversed by the same dopamine neuron, which helped to create changes in the first place.

Scientists found that when the dopamine neuron was hired to create a new memory, it also lowered old memories.

Jacob Berry, the first author in post-doctoral study at the Department of Neuroscience at Scripps Research's Florida campus, said: öğ When you learn something new, you are potentially interfering or deleting old ones while creating a new memory at the same time. It is a very important balancing act that prevents you from overloading. "

First author Ron Davis, Ph.D. He said, ine For decades, neuroscientists working on learning and memory have focused on how the brain receives knowledge, and how this information is made into a stable memory as a memory memory. More recently, neuroscientists have recognized the importance of active forgetting and have begun to solve processes that will forget the brain. "

Berry said: müdah This learning and forgetting process helps explain backward intervention, a common observation in psychology. Retroactive noise identifies the situation in which new information appears when trying to remember older information (for example, calling your old boss with the name of your current boss).

According to scientists, the findings will be applied to higher organisms, including humans. The study not only provides new insights into brain mechanisms for active forgetfulness, but also provides a great example of how much we learned about brain function from laboratory animals, such as the fruit fly, Drosophila.

Published in Working Cell Reports.


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