Friday , August 19 2022

Post-menopausal weight loss due to breast cancer risk


(Reuters Health) – A large US study in weight gainers suggests that the risk of developing invasive breast cancer may be lower than that of ongoing or weight gainers.

While obesity has long been associated with the risk of developing breast cancer, previous research has presented a mixed picture of the weight-loss potential to help reduce this risk. For the current study, researchers evaluated the weight and height to calculate the body mass index (BMI) for more than 61,000 women twice a year with three years apart.

Then, the researchers followed women for an average of 11.4 years. During this time, 3,061 women developed invasive breast cancer.

Women who lost at least 5 percent of their body weight during the first three years compared to women who had stable weight in the first three years of the study were found to be 12% less likely to get breast cancer in the next ten years.

”Our results are consistent with the fact that a woman can reduce the risk of cancer even if she is overweight or obese after reducing her weight because in our current cohort analysis, almost none of the women lost enough weight to reach normal weight,“ he said. Dr. Duarte, California Research Center for Hope National Medical Center. Rowan Chlebowski.

Chlebowski said in an e-mail, kayb This should be an encouraging result for women, since weight loss is quite difficult for women to return to a non-obese or overweight category, as a humble weight loss for women may become accessible to many people .

All women in the study had menopause when the menstruation stopped and hormone estrogen production decreased. After menopause, the main source of estrogen in women is fat tissue; Being overweight or obese can increase the risk of cancer because estrogen can help grow tumors.

Not included in the study from the Medical School of the University of Cincinnati. Ris Women who are overweight or obese are at increased risk of postmenopausal breast cancer due to increased hormone levels associated with fat cells, Daniel said Daniel Schauer.

Edi These hormones, especially estrogen, can support the development of postmenopausal breast cancer, post Schauer said in Reuters Health by email. ”Losing weight reduces the levels of circulating hormones.“

Among the 41,000 women who had a stable weight during the first three years of the study, the participants had an average of 26.7 BMI, which was considered to be overweight.

12,000 women who gained weight during the study started with an average of 26.7 BMI.

The women who lost weight started heavier.

About 3.300 women, who had unwanted weight, started with 27.9 BMI and lost more than 17 kilos. Women who knew how to lose weight, started with an average BMI of 29.9, only 30 BMI was thought to be obese and half of them lost more than 20 kilos.

In Cancer Journal, the 5 percent or more weight gain was not associated with an increase in breast cancer risk. However, this weight gain was associated with a 54 percent higher risk of developing lü triple negative ü breast cancer, an aggressive and difficult to treat type of cancer.

The study was not a controlled experiment designed to demonstrate whether weight changes over time directly affect women's risk of developing or developing breast cancer.

The researchers measured the weight of women twice at the beginning and three years after the study, and the weight changes reported thereafter were not confirmed by medical examinations.

For most people, the weight over time is terrifying. Dr. Louis Washington University School of Medicine in St. Louis. Graham Colditz did not participate in the study.

Tır So, the first realistic goal is to try to stop winning. Even if you're overweight, there are health benefits,, added Colditz by email.

”After that, it's a good goal to lose weight sensitively and slowly, Cold added Colditz. ”Five to 10 pounds is a great start, more easily protected over time.“

SOURCE: Cancer, online 8 October 2018.

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