Wednesday , April 14 2021

Scientist in China advocates human embryo gene regulation | Science



The Chinese scientist, who claimed that the twins changed their DNA before birth – said that he was proud of his work – without going through the usual scientific channels – and that another woman registered at his trial claimed to be pregnant with a similarly altered doll.

Scientist He Jiankui spoke to hundreds of colleagues and journalists at the Hong Kong University International Human Genome Regulatory Summit on Wednesday.

He said that the details of the first births obtained from the trial using gene regulation technology known as Crispr-Cas9 were sent to a scientific journal, which he did not name. He also didn't say when the results could be published.

In a planned presentation, He described how he used Crispr-Cas9 to modify a gene called CCR5 in a set of embryos created by IVF for HIV-positive fathers and couples in the South, associate professor at the University of Science and Technology.

The modification was intended to reflect a natural mutation found in a small percentage of humans that made humans resistant to the virus. Nana and Lulu two girls were born with genetic changes, he said.

The 40-minute Q & A of the researcher suggested a paid forum for scientists to question a controversial colleague publicly.

Nobel laureate David Baltimore, the organizer of the summit, who serves as a professor of biology at the California Institute of Technology, works irresponsibly. ”I think the lack of transparency is the failure of self-regulation by the scientific community, Baltimore said Baltimore.

David Liu, a biologist at Broad Institute in Cambridge, Massachusetts, challenged the idea of ​​how girls could benefit from changing their DNA. The children were not at risk of congenital HIV transmission and said there were many ways to prevent HIV infection in their later lives. U What was the unmet medical need, especially for these patients? Bu Liu asked.

In defense, he said: ada I believe that they need this protection not only for this case, but also for millions of children because HIV vaccine does not exist. I'm proud of it. "

Matthew Porteus, a professor of pediatrics at Stanford University, said, ris He's already at risk of becoming a pariah. Diy Scientists met with many of his colleagues years ago when they were working plans. , As long as it doesn't start to participate in the scientific process, it will get worse, Port said Porteus.

At the summit, he presented slides to an audience of scientists who expressed concern that he might harm his subjects and endanger gene-regulatory research.

But the scientist said he wanted to prevent HIV from being inherited from a parent, because many children in China were affected by the virus. Eight couples agreed to participate in the study, although one had fallen. Both, while the father was HIV positive, the woman was far from the virus.

He told the audience that he worked on 31 eggs and placed two modified embryos in a woman. One of the babies had only one copy of the CCR5 gene, which was not enough to accept HIV resistance. The health of both children will be monitored for the next 18 years.

The gen-editing work had begun three years ago, he had consulted and consulted in part with himself, with several colleagues about his plans.

It is illegal to create genetically modified babies in the United Kingdom and many other countries, and scientists in this field have reached a very unethical consensus to try. Genome regulation is not considered safe, and any genetic modification – whether useful or unwanted – affects not only children, but also children and future generations.

Kathy Niakan, a scientist from the Francis Crick Institute in London, said, Londra It is impossible to overestimate how irresponsible, unethical and dangerous it is right now Z. Ine He was concerned that the clinical plans were overlooked or revised before starting human experimentation and without complete transparency throughout the process.

Ilgili I was very annoyed that he refrained from answering questions about the approval process and did not trust me with the patient's response to his consent. The team does not seem to have received sufficient training in appropriate approval processes. Free IVF treatment for vulnerable patients presents a clear conflict of interest. "

In a statement Tuesday, he announced that he had been investigated by Chinese authorities and his university in Shenzhen.

The uncertain answers at the summit asked more questions from the audience. Did he know enough about the technology to ensure that the children were healthy or engaged in other deadly viruses? He said he knew enough.

; How do you see your responsibility to these children? # Ebru Kirksey asked Professor of Anthropology at Deakin University in Victoria, Australia. He said that the medical care of the children will be provided but no details are presented.

Missing information disappointed most of the audience. “It's a red line, Bir a conference participant said. "Why did you choose to cross it and do it in secret?"

Robin Lovell-Badge, a geneticist from the Francis Crick Institute in London, claimed that he was misguided. Di Clearly made the wrong decisions. I'm so critical of this breakthrough as a scientific breakthrough because it all went well. "

Lovell-Badge said the infants tend to believe that they changed their DNA, but the scientist should show proof. The only way to convince the world is to test the DNA of an independent, qualified laboratory, parents and two babies, and show that the genes are arranged. Iğ Nothing I'm showing says it's not wrong. But the evidence I have seen is not good enough yet, Ama he added.


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