Friday , July 30 2021

1-View Digital Breast Tomosynthesis with High Sensitivity for Breast Cancer Detection



This article initially appeared in Clinical Advisor.

Single-image digital breast tomosynthesis with reduced compression force detected breast cancer with higher sensitivity and lower specificity than 2-image digital mammography.
Single-image digital breast tomosynthesis with reduced compression force detected breast cancer with higher sensitivity and lower specificity than 2-image digital mammography.

In one study, the use of 1-image digital breast tomosynthesis with reduced compression force during breast cancer scans, compared to a study, can reduce radiation dose and scan loads 2-view resulted in lower sensitivity to higher sensitivity and lesion detection compared to digital mammography published Lancet Oncology.

A group of investigators for the Malmo Breast Tomosynthesis Screening Study (MBTST; ClinicalTrials.gov Identifier: NCT01091545) conducted a prospective, population-based, diagnostic accuracy study comparing the accuracy of 1-view digital breast tomosynthesis with 2-view digital mammography on the breast. Diagnosis of cancer.

Non-pregnant women aged 40 to 74 were asked to participate in the national breast cancer screening in Malmö, Sweden. The women included in the study (n = 14,848) were screened by 2 breast enlargement digital breast mammography, followed by 1 breast digital imaging with reduced compression and 1-image digital breast tomosynthesis.

The sensory sensitivity and specificity were the primary outcome measured; secondary results include screening for cancer diagnosis, recall and intermittent cancers as well as positive predictive value for screen recall and negative predictive value for both methods.

The researchers reported that digital breast tomosynthesis had a higher sensitivity (81% vs 60.4%) compared to digital mammography, but marginally lower specificity (97.2% vs 98.1%). A total of 8.7 cancer cases, corresponding to 6.5 cancer per 1000 women for 1000 women, showed that cancer detection was significantly higher in 1-picture digital breast tomosynthesis compared to 2-vision digital mammography.

In cancers detected by tachosynthesis, a larger percentage of women were recalled after discussing with digital mammography (3.6% and 2.5%, respectively). Positive predictive values ​​for screen recall were 24.1% and 25.9% for digital tomosynthesis and digital mammography, respectively; Negative predictive values ​​were 99.8% and 99.6% for digital tomosynthesis and digital mammography, respectively. After the trial screening, every 1000 women developed cancer with 1.48 intervals.

In As a result, breast cancer screening [1]- higher sensitivity than digital breast tomosynthesis with low compression force and slightly lower specificity for breast cancer detection [2]it had the ability to view digital mammography and lower the dose of radiation, and could reduce the reading burden. [2]- visual digital breast tomosynthesis [2]Look at digital mammography, bakış writes researchers. “Supported by cost-effectiveness studies, [1]The view of the tomosynthesis of vision guarantees the evaluation as the preferred method of breast cancer screening in the future. "

Reference

  1. Zackrisson S, Lång K, Rosso A et al; MBTST for operation. Single-look breast tomosynthesis against two-sided mammography in Malmo Breast Tomosynthesis Screening Trial: prospective, population-based, diagnostic accuracy study [published online October 12, 2018]. Lancet Oncol. DOI: 10.1016 / S1470-2045 (18) 30521-7


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