According to new findings, a specific genetic factor may play a role in predicting tardive dyskinesia (TD).
A multinational research team conducted a meta-analysis of 2 data sets to determine the relationship between a specific gene and the formation of tardive dyskinesia. They also added their own new data for analysis.
The first data set included 217 patients diagnosed with schizophrenia from the US and Canada. The second group of patients included 20 patients with schizophrenia and 41 patients with schizophrenia without TD.
A previous study showed that the HSPG2 gene or Perlecan gene was significantly associated with tardive dyskinesia in Japanese schizophrenia patients, and a subsequent independent study was able to confirm the findings. Another study examining the deficiency of the HSPG2 gene in schizophrenia patients in Europe and Israel has shown that, as in mouse models, undesired chewing movements are reduced.
Perlecan gene mutations have emerged due to chondrodystrophic myotonia or Schwartz-Jampel syndrome and the aging of skeletal muscles. Perlecan is also part of the mixture that forms the blood-brain barrier, and it is even possible for researchers to play a neuroprotective role following ischemic stroke. Researchers, researchers have more information about the Perlecan gene, the role of proteins in TD is understood better understood.
The researchers obtained allele counts for patients with tardive dyskinesia and performed checks for their research, including both sets of data. The works included Japanese, Jewish, European, and African-American.
The authors reported that the original data did not show any significant TD formation or severity as measured by (AIMS) scores. In other examples from the meta-analysis, the gene was not associated with transformed AIMS scores or tardive dyskinesia.
The authors found that the G allele was significantly associated with tardive dyskinesia in a total of 324 TD patients and 515 TD negative controls. There was no significant heterogeneity in studies, including in meta-analyzes.
After filtering the study results according to their age, the researchers learned that they affected the findings. A tendency to filter for sex turned out to be a trend, they wrote.
All of this led the researchers to believe that the risk of tardive dyskinesia reflects multiple genetic factors. The use of long-term studies involving looking at fluctuations in tardive dyskinesia may one day further support this idea.
Ası International efforts need to provide additional independent replications in large samples, especially for genetic associations with small impact sizes, Araştırma the researchers said. Anlamlı Moreover, the frequency of small allele frequencies was different from that of ethnic origin, and the findings could be more meaningful for East Asian specimens with original findings. “
Patient replication studies in different ethnic groups may give an idea of whether the genetic relationship is particularly strong in Eastern Asians.
M The Investigation of HSPG2 Genes in Tardive Dyskinesia – New Data and Meta Analysis P was published in the journal. Boundaries in Pharmacology.