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Work life changed the development of cognition in people at risk for Alzheimer's, study demonstrations



Dr. New York-Presbyterian / Weill Cornell Medical Center Alzheimer Prevention Clinic, the founder of the neurologist Dr.. "Our data is actually showing cognitive improvement," said Richard Isaacson.

"This is the first study in a real-world clinical setting that personalized clinical management can improve cognitive function and also reduce Alzheimer's and cardiovascular risk," Isaacson said. Said.

Alzheimer's disease begins in the brain 20-30 years before the onset of symptoms. An estimated forty-seven million Americans currently live with such a preclinical Alzheimer's. There's no medicine to help them.

Some may be experiencing subtle symptoms of cognitive loss; others are still blind to the growth of destructive records and wandering that are condemned to steal their memories.

There is increasing evidence that some lifestyle changes, such as diet, exercise and brain training, will slow down mental retardation and even protect them from developing full-blown dementia.

But does a body fit everyone? Or do we each need a unique action plan tailored to our specific risk factors?

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Isaacson bet the second. Since 2013, customers at the Alzheimer's Prevention Clinic have undergone physical and mental testing. MRI scans are performed to check for early signs of amyloid plaque deposition. Current and past medical problems, genetics, family history, nutrition patterns, exercise habits, stress levels and sleep patterns have been documented.

They are also asked if they want to participate in a research.

"Our study was designed to look at the effects of lifestyle intervention on cognitive function," Isaacson said. Mı Does cognitive function decrease? Will it remain the same or will it probably improve? ”

Isaacson and his team managed to register 154 patients in their family aged 25 to 86 years, all with Alzheimer's history. Most of them have not yet suffered from memory loss, but showed a worrying performance in cognitive tests.

A small group of 35 people was diagnosed with mild cognitive impairment (MCI). The Alzheimer's Association defines MCI as “there are severe cognitive changes that are noticeable by the affected person and family members and friends, but do not affect the individual's ability to perform daily activities”.

Based on these results, each person was given a personalized prescription plan. Nearly 50 evidence-based interventions were each given 21 lifestyle behaviors to implement.

"Physical activity and nutrition were the two most important things on the list, but they were personal for each individual," Isaacson said. Said.

For example, in physical activity, the program may recommend aerobic interval training for one person, while it may be advisable to use a balance ball or weight table training for another table.

Regular aerobic exercise can slow progress to Alzheimer's for those at most risk

Isaacson, "In the diet, only 2 hours before noon can say to consume caffeine coffee. 12 or more hours per day for carbohydrates – this intermittent fasting protocol." Said.

The program studied alcohol intake, milk intake, minerals and vitamins, sleep hygiene tips, training to learn something new, listening to music, meditation, awareness and more.

The results were hopeful

Isaacson found people diagnosed with mild cognitive impairment who had better memory and thinking skills in at least 17 out of 21 behavioral changes after 18 behaviors.

MCIs who did less than 17 of personalized behaviors did not improve. In fact, they kept falling.

The second group of patients with genetic risk but without the symptoms of dementia, called the preventive group, received equally impressive cognitive support. It was not important that the recommendations followed less than 60%.

Isaacson is cautious about exaggerating the meaning of these results. This study was not designed to prevent Alzheimer's disease, but was designed to see if lifestyle changes affect cognitive function.

"We need more research, we need more clinics and more doctors," he said. “But I think this model is a roadmap for doctors and patients to work together to improve their brain health.

Yerine We're foresee a day when people can go to their doctor, and instead of hearing that there's nothing you can hear, the doctor will say: # Well, we may not have the perfect answers, but here are 21 different things you can do to protect your brain health. "


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