Friday , October 22 2021

Pharmacotherapy, new hope against antibiotic resistance



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These are the words that doctors and associations hear more often. "I have a staphylococcus aureus, I have no solution, I am telling you to amputate". In France, many patients infected with a bacterium resistant to antibiotics are looking for a solution for desperation.

In this global week, it should be said that it is urgent to find an alternative to their good use. Excessive consumption of these patients, the length of hospitalization, the death rate in our country is rising up to 5 500 per year. And if nothing is done at the global level, this phenomenon could lead to the death of 10 million people in 2050.

READ ALSO>Antibiotic resistance: "We can't say we have no solution"

Thus, in this black table, patients are whispering as a last resort treatment, in some of them a miracle, whispering to the fatiate. What are we talking about? Phage medicine, natural viruses are everywhere, are responsible for bone and lung infections by eating in soils, lakes, sewers and even the most difficult bacteria.

"He cured thousands of patients in the 1980s"

This technique, which was rediscovered in France, is common in Georgia, which has long preserved this knowledge that has been deprived of the Western antibiotic. "We have 300 patients a year," says Alain Lavit, assistant manager of a medical tourism company in Eastern Europe.

So phagotherapy can really save us? Alain Dublanchet, a microbiologist and expert, believes this. Başar Before being buried in France in the 1980s, he treated thousands of patients before confronting the success of antibiotics. Pasteur's labs had phage collections, everything was thrown. We stopped this drug.

So, you have to start over again. In 2016, a French company was able to produce antibiotics as well as tested, quality phages in some serious patients, especially in the Croix-Rousse hospital in Lyon. Most of them suffered from very serious infections. "There are no signs of infection in the 4th agreement," said Tristan Ferry, deputy chair of the Department of Infectious Diseases. This is a great success, we are at a turning point in phage history. "

Only one week ago, a 6th patient received this treatment. "The doctor who hopes to treat ideal infections," he said.

New clinical trials

Even though these few cases seem to be important, authorizations are still delivered droplets in Hexagon. Then why don't you export phage from Georgia? According to Caroline Semaille, products manager in the pharmaceutical sector, "there is no way to know their quality". The path is long to develop this therapy at home. We don't yet know how to produce them on a large scale.

”If this therapy comes up with many questions, it's full of hope,“ he said. So we have to continue the research. "As soon as there was more production, we announced the director, we will make temporary authorizations for use".

New clinical trials will be conducted and review committee is planned at the beginning of the year. Other solutions continue. A company has also developed a technique to pierce the double membrane of the most challenging bacteria. The doctors and authorities hope to remove France from the current therapeutic impasse.

KEYS

  • 40 million euros to fight against antimicrobial resistance.
  • 759 t antibiotic sold in 2017 for human health and 499 t for animals.
  • France 4to consumer 8 of Europeto in the world.
  • Only 2 new antibiotics have been in the market for the last fifty years.
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