Experts say that common painkillers, statins and fish oils, especially when taken with antidepressants, can help prevent depression.
A recent review found that painkillers such as ibuprofen and aspirin, as well as anti-inflammatory agents such as statins and omega-3 fish oils, can reduce the symptoms of major depression, such as low mood.
Experts from China's Wuhan University of Science and Technology reviewed 26 existing studies for their research in the Journal of Neurology, Neurosurgery and Psychiatry.
Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and aspirin; The omega 3 fatty acids commonly found in fish oils; cytokine inhibitors; statins; steroids; antibiotics; a medicament (modafinil) used to treat sleep disorders; and N-acetyl cysteine used to loosen excess sputum in people with cystic fibrosis and chronic obstructive pulmonary disease (COPD).
Overall, the results showed that these drugs and agents were 52% more effective than placebo in reducing the symptoms of general depression and 79% more effective than placebo in relieving symptoms.
The most effective drugs were found to be NSAIDs, omega 3 fatty acids, statins, and minocycline, and the effect was greater if they were added to antidepressants.
However, the researchers said that there is no clear link to improve the quality of life, but this may stem from the few studies reviewed.
In conclusion: "The results of this systematic review show that anti-inflammatory agents play an antidepressant role in patients with major depressive disorder and are reasonably safe."
Professor Ed Bullmore, Head of the Department of Psychiatry at the University of Cambridge welcomed the study, but said: "This should perhaps encourage further consideration of the ways in which we can use a range of anti-inflammatory interventions to help patients with depression, perhaps with a particularly limited benefit, as a traditional antidepressant. People taking medicine.
“However, as the authors concluded, further trials will be needed to support the licensing of these and other anti-inflammatory agents and their medical prescription for depression,” he said.
Professor David Curtis, an honorary professor at College College in London, said he was not convinced by the findings.
Furthermore, it is quite misleading to explain the safe use of antiinflammatory agents.
"The most effective anti-inflammatory agents used were NSAIDs, and although problems are rare, thousands of people die each year from the side effects of these drugs, which are often taken for chronic pain and are particularly risky if taken over long periods of time."