The researchers thought that being overweight could lead to depression and was thought to be largely psychological.
Although earlier studies have found that people with obesity are more likely to suffer from depression, it is not clear whether this is in contrast to weight change or in contrast to depression.
Now, in its largest study of its species, experts say that genetic variants associated with high body mass index (BMI) can lead to depression that has a stronger impact on women than men. Moreover, they say that the research suggests that the effect can be reduced to factors such as the body image.
Bun People with more population are more depressed, and at least in part. [a] BMI causal effect [on] Depression, Dep he said. One of the co-authors of the study is Prof Tim Frayling, Exeter Medical School.
In the International Journal of Epidemiology, researchers in the United Kingdom and Australia describe how they used data from the UK Biomark, a research study involving 500,000 participants between the ages of 37-73 employed in 2006 and 2006.
Researchers have also examined 73 genetic variants associated with a high BMI which are also associated with a higher risk of diseases such as diabetes and heart disease. They also examined 14 genetic variants that were associated with a high percentage of body fat but were associated with a lower risk of such health problems.
The team then examines the participants' hospital data and answers to a series of questionnaires – including a GP or their reports on psychiatric referral for anxiety or depression. The team found that about 49,000 respondents were confident in their depression.
Overall, the team found that people with a higher BMI were more likely to be depressed.
Researchers found that predisposition to a genetically higher BMI was associated with depression by showing a stronger effect on women than men. The results were maintained when individuals with a family history of depression were excluded and the analysis performed additional tests even when the analysis was repeated with data from a large international project called the Psychiatric Genomic Consortium.
73 focusing on genetic variation and taking into account factors including age and gender, it was found that the increase in depression for each 4.7 point increase in BMI increased by 18% in general and 23% in females.
When collecting data from different sources, the team found 14 genetic variants that increased body fat but were not associated with metabolic disability, and increased the chance for depression.
Bileşen If the psychological component is as strong as any physiological component [the latter] there is no, ğ Frayling said, suggesting that a weak body image might be a mechanism in play.
The study has some limitations: it looked primarily at individuals with white European ancestors and some contained their own reported data.
While the study did not show that for other reasons weight gain would increase the risk of depression, Frayling said this was possible. "They're giving permission [one] He said the larger impacts in the BMI could have a greater impact on depression. BM
Naveed Sattar, professor of metabolic medicine at the University of Glasgow, welcomed the study. ”These new findings are perhaps the strongest to suggest that higher weights may actually contribute to depression,“ he said. ”Of course, many other factors can lead to depression, but they can even help in weight loss in some people, while the weaker should help reduce the likelihood of depression in general.“