Sunday , December 6 2020

A team of scientists told the mechanism of passive drug delivery to cells health



PRAGUE In collaboration with colleagues from the Czech Republic and Germany, the Pavel Jungwirth team from the Organic Chemistry and Biochemistry Institute of the Academy of Science of the Czech Republic described an unknown passive peptide transfer mechanism to non-mediated cells. Easy transport of drugs directly to cells is one of the objectives of the pharmaceutical industry. The Institute reported this in today's press release. The research results were published by the National Academy of Sciences (PNAS) of the United States.

The ability of short peptides to penetrate cells was first observed in HIV studies and is now used to transport drugs to cells. Up to now, it is most often done with a transport pouch called a vesicle, which surrounds and removes the material that is separated from the cell membrane. The recovered molecule must be released again from the bag, according to scientists, it may be a technical complication for the effective transport of the drug.

Peptides can pass to cells without passive energy assistance. Jungwirth & apos; s team, using fluorescence and electron microscopy and computer molecular simulations, revealed a mechanism based on membrane fusion induced by the carried peptides themselves. However, according to Jungwirth, practical use of discovery can only be speculated.

Medications (Sample picture)

With the Jungwirth team, he has been working on molecular processes in the cell membrane for a long time, opening up new possibilities to control these processes and potentially offering more effective ways to transport drug molecules to the action site.

He has published more than 280 books in international journals such as Jungwirth, Science, Nature Chemistry and PNAS. He is also an editor of The Journal of Physical Chemistry, published by the American Chemical Society. In addition, Respekt has made science popular in Czech Radio and Czech Television.


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