Tuesday , June 15 2021

Scientists managed to partially renew the legs of amputated frogs



The findings of this study may be a model for new cell stimulation therapies and may lead to progress in the treatment of amputation injuries in humans.

Rana Dendropsophus kubricki.Pablo Venegas

A team of scientists from American Tufts University, according to the Cell Reports magazine, managed to partially renew the legs of the amputated frogs with a progesterone treatment using a wound-attached portable bioreactor.

The findings of this study may be a model for new cell stimulation therapies and may lead to progress in the treatment of amputation injuries in humans.

Some species of the animal world, such as lizards or crabs, can regenerate themselves, but this does not happen in the African nail frog, which is known by the scientific name of Xenopus laevis and studied in this study.

This kind of water frog can rejuvenate its limbs in the early stages of life, but it loses this ability in adulthood.

The researchers divided the frogs into three groups to perform their experiments and all were planted with a portable bioreactor in place of the wound left by amputation.

Only frogs of one group received progesterone from the bioreactor for a period of 24 hours, and the researchers observed partial regeneration of the limbs not seen in the other two groups over a period of nine months.

"A very short administration of the bioreactor and its charge (progesterone) resulted in months of growth and tissue patterns," he explained. One of the authors of the study and Michael Levin, a biologist at the Allen Discovery Center at Tufts University in Massachusetts. (USA).

Progesterone-treated frogs had partially regenerated legs, bones, innervation and vascularity, and could swim as if they had never been cut.

Progesterone is a known sex hormone for its functions at the beginning and development of pregnancy, but it has also been shown to promote the repair of nerves, blood vessels and bone tissue.

U We looked at progesterone because it seemed promising to promote nerve repair and regeneration. It also regulates the immune response to promote healing and triggers the re-growth of blood vessels and bones, ı says Celia Herrero-Rincón, a neuroscientist who is the author of the study.

The next step for researchers is to carry out a similar study in mammals and try to obtain further evidence that the drug-device combination may be a new model for testing therapeutic cocktails that cause regeneration in non-regenerative species.

There are millions of people in the world, some limbs, down or top, amputated and only living in the US, in this case there are two million.


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