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Parents' biological clock works faster than previously believed – 02/12/2018



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Biological clock works for fathers. And recent research shows that it is much faster than previously thought.

If so fare was 55 years old When the age of the father may have some incidence on the health of the baby due to the greater accumulation of chromosomal changes in sperm, a new study is recommended from Stanford University School of Medicine, which has delivered more than 40 million deliveries. risks begin after 35 years and 45.

14% more premature babies among fathers over the age of 45

In particular, Stanford scientists claim that The higher the age of the elderly father, the baby has problems in the birth.Low-weight convulsions, assisted breathing or neonatal intensive care unit (NICU) should be consulted.

When the data published in English Medical Journal, such as maternal age, race, education, education level, marital status or smoking history were checked, When the age is over 35, there is a slight increase in the risk of birth. because each year, a man accumulates in two new mutations in the DNA of the spermin.

If the father is over the age of 35, there will be a slight increase in the risks in labor, because every year a man is the age at which his sperm accumulates in two new mutations in DNA.

If the father is over the age of 35, there will be a slight increase in the risks in labor, because every year a man is the age at which his sperm accumulates in two new mutations in DNA.

thus, Babies born in boys aged 45 years or older are 14% more likely to be born prematurely.NICU's low weighting and referral, parents aged between 25-34 years (average age of paternity in the United States). and increased risk of seizures, According to the report, 18% and After 50 years, the possibility of ventilation at birth was 10% higher and the rate of those in need of intensive care increased by 28%.

In particular, Stanford scientists say that the father's age is greater, and that the baby is at increased risk of having a problem at birth: the need to apply from low-weight to contractions, assisted breathing or care. Neonatal intensive care (NICU).

Rafael Oliva, a professor of epigenomics and epigenetic at the Clinical Biomedical Diagnostic Center as a professor in the molecular biology of Idibaps' reproduction and as a consultant in the Clinical Biomedical Diagnostics Center, was not surprised by these results. "Interesting job and what other studies have shown: the role of the father in pregnancy and his son's health is more important than we thought, and the man has a biological clock.

A new study, the greater the age of the father, the greater the risk that the baby will have problems at birth.

A new study, the greater the age of the father, the greater the risk that the baby will have problems at birth.

In addition, Julio Herrero, the president of Vall d'Hebron's assisted reproduction, believes that this work is relevant. The age of the male parent often points to an unobtrusive factor. because after 55 years it was thought to have little effect. However, it is thought that the concrete results of the study should be considered carefully, because it is a retrospective study, which is made up of the forms that doctors or parents fill with 40 million births. age is too large to assess whether the risks attributed to the age of the father will not affect the age of the couple or the consequences of having the first child for that woman. "The important thing is to emphasize the necessity of researching the age of paternity and the incidence of male biological clock. with more depth, but should be done prospectively and should be taken as the control group of older parents and elderly parents, "says Herrero.

Androlog Alvaro Vives, who is in charge of the Dexeus Men's Unit, admits that although a study on such a high number of cases acknowledges that it is difficult not to have a certain bias, they have more changes at the chromosomal level as male age. and may cause problems in the fetus. Or In fact, in Catalan public health, access to in vitro fertilization is limited if the woman is over 38 years old or 55 years old, “she explains. Vives believes that many fertility centers are run by gynecologists and will focus more on women's conditions.r, "but 50% of fertility is the responsibility of the human being, and there are many factors and habits – the consumption of toxins, coffee intake, tea, overweight, tobacco … – this effect" the quality of sperm and the development of both fertility and pregnancy alterations that affect premature babies or respiratory problems, as indicated by the Stanford study.

"This is an interesting work and is consistent with what other studies have shown: the role of the father in pregnancy and the health of the child is more important than we thought, and at the same time the male biological clock"

Rafael Oliva, epigenetic and sperm epigenomics specialist

At the 2017 European Conference of Reproductive and Embryology, a study was conducted by biologists from Harvard University after analyzing 19,000 in vitro fertilization treatments. Pregnant women were more likely to fail when young women attempted to have a boy older than 40 years. On the other hand, when the man did not reach his thirties, the results were better.

A new study, the greater the age of the father, the greater the risk that the baby will have problems at birth.

A new study, the greater the age of the father, the greater the risk that the baby will have problems at birth.

Oliva from the epigenetic field, despite the fact that there is still little information about everything transferred by sperm in humans, proves that animals in the last two years have accumulated the lifestyles of animals. Who's eating their experiences? causes measurable changes in your sperm and is transferred to the next generation and sometimes even third.. Içer We focus on the concern about mothers because the oocyte is very large compared to sperm, and a long time ago, through the cytoplasmic factors of the oocyte, where DNA had inherited more than the maternal, because the sperm was believed to contain only DNA; but today, it is clear that the genome of the sperm is organized by histones and protamines, which have the potential to provide epigenetic information sperm, summarizes the Idibaps researcher.

This week's science magazine, PNAS, reiterated that a team of doctors in the United States ended the belief that mitochondrial DNA – cells that give energy to cells – was transmitted only by mothers. More than a dozen people in three different families carrying the mitochondria heritage of both parents. The researchers, however, think that the general rule is the exception, which is when the paternal mitochondria become a chemical label that allows them to destroy them when they enter the zygotes. But, The finding is that the biological heritage inherited by a person goes beyond the gene sequence, and that life, habits, and the environment have both left their mark on both parents.

Source: La Vanguardia

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