An investigation in the United Kingdom, monosaccharidesknown as mannose, blueberries, oranges and apples may delay growth tumors and increases its effects chemotherapy.
The tests were performed on multiple cancer mice and will need to be tested in humans, but it is a step to understand how mannose can be used. help cure cancer, The researchers stated, stated Cancer Reseach UK
Tumors use more glucose than normal and healthy tissues. However, it is very difficult to control the amount of glucose in your body by diet. In this study, the researchers mannose It can block glucose to reduce the amount of sugar that can be used by cancer cells.
Kevin Ryan, the lead author of the Beatson UK Cancer Research Institute, said: "Tumors need too much glucose to grow. It slows the progression of cancer. The problem is that normal tissues need glucose, so we can't destroy it completely from the body. "
"In our study, we found a dose of mannose that could inhibit enough glucose to slow tumor growth in mice, but not until normal tissues are affected." This is the first attempt, but that means hoping to find the perfect balance. , may be in the future Mannose application to cancer patients To improve chemotherapy without damaging your overall health. "
The researchers examined how mice react with pancreatic, lung or skin cancer when added. mannose It was applied to drinking water and oral treatment. They found that the addition of the insert significantly reduced tumor growth and did not cause any significant side effects.
In order to test how mannose may also affect cancer treatment, the mice were treated with cisplatin and doxorubicin, one of the two most commonly used chemotherapy drugs. They found mannose improved the effects of chemotherapy, reduced tumor growth, reduced the size of tumors, and even prolonged the life of some mice.
Other types of cancer, such as leukemia, osteosarcoma, ovarian and intestinal cancer, were also investigated. The researchers used cancer cells in the laboratory and then treated them with mannosis to see if their growth was affected.
Some cells did not respond to treatment, while others did not respond. It has also been found that a disintegrating enzyme exists. mannose in cells It was a good indication of how effective treatment was.
Professor Kevin Ryan added: sadece Our next step is to investigate why patients work only in some cells to determine which patients can benefit most from this approach. We hope to begin as soon as possible to determine their true potential as a new human being in clinical trials. cancer treatment ".
Mannose is sometimes used for short periods to treat urinary tract infections, but long-term effects have not been investigated. It is important to do more research before using mannose in patients with cancer.
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