Scientists reported the first successful delivery of a baby from a donor who died from a transplanted uterus. It can pave the way for many women with groundbreaking infertility problems.
For some women receiving uterine transplant is the only way to get pregnant. However, to date, donations were limited to donations of volunteers.
Low number of donated organs slows down the procedure
Uterine donation is a serious decision and complicated procedure. To date only 39 transplants have been performed worldwide and since 2013 only 11 live births have taken place.
The ability to use the uterus from dying patients reveals the possibility of more organs, but in the ten trials so far, only this last birth has resulted in a successful birth.
Scientists from the University of San Paulo have published a successful transplantation and birth event in The Lancet.
Transplant donor born without uterus
Birth mother and donor-recipient, 32-year-old woman who was born without a uterus. Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome.
TThe donor was a 42-year-old female.
A few months before transplantation, the recipient passed an IVF procedure and 8 fertilized eggs were frozen. Uterine transplantation took 10.5 hours to complete.
Healthy baby girl born without complication
The recipient showed no signs of rejection and regular menstruation was seen after five months. Seven months after intensive surgery, fertilized eggs were implanted and a healthy pregnancy continued.
The baby girl was born 35 weeks earlier by cesarean section, healthy baby weighed 2.5 kg (5.5 lb). The cried uterus was also removed during cesarean section.
The use of deceased donors leads to more fertility treatment
In the months following birth, neither the baby nor her mother had any problems.
"The use of deceased donors would have greatly improved this treatment, and our results provide evidence of a new option for women with uterine infertility," says Dani Ejzenberg.
Ejzenberg, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, led the research.
Transplant The first uterine transplantation from living donors was a medical milestone; this created the possibility of birth for many infertile women with access to appropriate donors and medical facilities.
However, the need for a living donor is an important limitation as donors are rare, typically with enthusiastic and appropriate family members or close friends.
The number of people willing and willing to donate their own deaths is far greater than that of live donors who offer a larger potential donor population. "
Doctors will continue to investigate
As doctors are excited by the results, they still warn the procedure at an early stage and need more research and collaboration before becoming a common option for infertile women.
Writing on Linkedin Dr Antonio Pellicer, Italy IVI-Rome, said;
As a result, research in this area (whether from living or deceased donors) should maximize live birth rate, minimize the risks of patients involved in procedures (donor, recipient and unborn child) and the availability of organs.
With the expansion of the field, the number of procedures will increase and this will allow the community to create different study designs, such as comparison studies (ideally randomized) or long prospective series.
The role of collaborative networks in an expanding area such as uterine transplantation and societies such as the International Society of Uterine Transplantation or new interest groups in already existing scientific societies will be very important. "