Clinical use against autoimmune diseases, allergies and cancer
"Autoimmune diseases and allergies are among the most common diseases worldwide, and therapies are urgently needed. Here is our discovery Be tremendously useful. if so BH4 It inhibits the continuous attack of these autoagressive T cells, so they do not destroy healthy tissues or cause chronic inflammation, "he said. Shane CroninPostdoc in the IMBA, and the first author of the current publication nature,
Clifford Woolf Boston Children's Hospital Harvard and Kai Johnsson. Max Planck Medical Research Institute HeidelbergThe researchers developed a new drug called QM385. BH4 obstacles and immune cells "tames" with submissive reactions. The first clinical trials offing.
Is BH4 also for cancer therapies?
BH4 Also, as activated T cells detect and fight cancer cells, they are an important candidate for future cancer immunotherapies. Researchers in mice BH4 T cells help target the tumor. Also appeared appeared BH4 a molecule that can be blocked by kynurenine immune system tumors may be closed. Present BH4 It allows T cells to grow again.
Valuable information about relationships
In The knowledge of new relationships in the emergence of biology and diseases is particularly valuable because applications can be multifaceted. Who knows that ours immune system it is controlled by a molecule known from neurobiology and possibly new applications. Autoimmune diseasesEven asthma can lead to cancer and immune deficiency! " Shane Cronin,
"If he manages to find the cross-links of different biological systems in the body, then the nervous system and immune systemSometimes you can be great discoveries In the past, about the surrounding team Josef Penninger Using the example of the RANKL signaling pathway, it was possible to link the bone metabolism and the hormone system. The use of the drug denosumab interval of the emerging drug, is currently