Tuesday , July 27 2021

How does immunotherapy use our immune system to attack cancer?

Our usual defense against the disease is our immune system. It does an excellent job to sort things out of the body and attack it – when it comes to cancer. For 100 years, the reasons behind this failure were a mystery. Jim Allison's [immunotherapy] Progress was to realize that the immune system did not ignore cancer. Instead, cancer took advantage of the tricks that closed the immune system. But could you stop these tricks and release the immune system's killer T cells against the disease?

Allison found that the immunology laboratory at Berkeley, University of California, found a protein called CTLA-4 in the TTL cell. When stimulated, the CTLA-4 acts as a circuit breaker on the immune response. These brakes, called control points, have prevented cell killers from being uncontrolled and disposing of healthy body cells. Cancer used these brakes to survive and develop. In 1994, the laboratory developed an antibody that blocks CTLA-4.

What they found would eventually win the Nobel Prize. It would also fly about what practitioners oncologists were taught and how to deal with cancer.

Seven years after approval [the] The first control point inhibitor was reported to be tested by one million cancer patients in more than 3000 clinical trials in the clinic, half of the 940 & new öncesi cancer immunotherapeutic drugs in the preclinical phase above 1,000 İlk.

Read the full and original post: Cancer treatment: how to kill a killer

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