Da Scientifically high levels of cortisol predict stress hormone, brain function, brain size, and cognitive tests, ve says Sudha Seshadri, author and professor of neurology at the University of Science Center. The health of the University of Texas at San Antonio.
"We discovered that the brain's memory loss and contraction can be noticed in relatively young people long before the symptoms are noticed." Said.
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Cortisol is one of the main stress hormones most commonly known for its "combat or flight" instinct. When stressed or stimulated, the adrenal glands produce more cortisol. The hormone then causes a suspension of various bodily functions that may prevent survival.
After the crisis, cortisol levels should decrease and body systems should return to normal. But if the alarm button is pressed, the body may continue to breakdown, causing anxiety, depression, heart disease, headache, weight gain, sleep problems and of course, memory problems and concentration.
According to experts, the brain is particularly vulnerable due to the amount of nutrients needed to function properly.
& The brain is a very hungry organ, şef said Keith Fargo, the science director of the Alzheimer's Association. "The study needs a lot of nutrients and oxygen to keep it going smoothly, so when the body needs these resources to deal with stress, there's less to send to the brain."
Intense stress is related to memory loss
Previous studies have found a relationship between the risk of developing cortisol and dementia; However, studies focused on the region in which the memory is located and called the hippocampus in the brain.
Among the advantages of the new study, according to Seshadri, a 48-year-old group of men and women were analyzed on an average basis and MRI was performed not only in the hippocampus but in the brain.
The researchers selected more than 2,000 people who did not show signs of dementia and who applied several psychological tests to assess their cognitive abilities.
They were all part of the Framingham Heart Study, a long-term study supported by the National Heart, Lung and Blood Institute of the United States. The study analyzed the health of Framingham, Massachusetts and their children since 1948.
The group was reevaluated approximately eight years after the initial tests. Blood cortisol was measured before breakfast. Magnetic resonances were performed and memory and cognitive tests were repeated.
It was determined that the highest cortisol levels were found to be highest after the data were adjusted according to age, gender, body mass and smoking.
Fargo, who was not included in the study, said, “I am not surprised by the change in consciousness. Çalış ”If you have a higher cortisol, you'll probably be stressed out and have more difficulty in cognitive testing.“
Stress also affects the structure of the brain
Fargo pointed out that what was surprising about the effects of cortisol on brain structure was discovered.
High levels of cortisol cause further damage to parts of the brain (radiant crown) and the hemispheres (corpus callosum).
In addition, the study found that the department responsible for brain, thinking, feeling, speech and muscle functions was less in people with higher cortisol levels.
In contrast to 88.7% of those with normal cortisol levels, the average brain volume of people with high levels of cortisol was 88.5% of the total brain volume.
. I was surprised to see such a big change in the brain structure with high levels of cortisol compared to moderate cortisol levels, F Fargo said. ”If you notice structural brain changes in middle age, you can imagine what happens when you're old enough to develop dementia.“
Interestingly, the effects of elevated cortisol on brain volume appear only in men, not in women.
Ell Estrogen can increase cortisol, 39 said Richard Isaacson, director of the Alzheimer's Prevention Clinic at the Weill Cornell University School of Medicine in the United States. "Approximately 40% of women in the high-cortisol group were on hormone replacement therapy." Isaacson did not participate in the study.
Seshadri said the study, which considers hormone replacement therapy, has made corrections. Olası This has not completely excluded the negative impact of hormone replacement, ini he added, but is less likely in this story.
Seshadri also emphasized that the results of the study were not just an association, but a relationship, and that further research was needed to determine the relationship between high cortisol levels and dementia. In doing so, he suggests that people should consider making changes in lifestyles to tackle the stress of modernity.
Fargo agrees. ”For example, we know that people who exercise during their lives are less at risk of developing dementia,“ he said. "Take time for yourself, meditate, there are always ways to control the stress that will give you positive results."
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