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Global discussion after announcement of first genetically modified babies



November 26, 2018 – 19:44
A Chinese man claims that twins have changed several embryos in their fertility treatments, where twins are already born. But there is attention in the scientific community.

A Chinese researcher claims to have helped create the first twin babies born this month and said that the DNA has changed with a new powerful tool that can rewrite the original life project.
If true, there would be a big leap in science with deep moral implications.
A US scientist said that they participated in the study of genetics in China and that it was banned in the United States because changes in DNA could be passed on to future generations and that other genes would be harmed.
Many scientists believe it is too risky to try, and some denounced that the Chinese report is equivalent to experimenting with people.

Challenge future HIV infection

The researcher, Jiankui from Shenzhen City, said that he changed embryos for seven pairs during fertility treatment and he has so far obtained a pregnancy. He said his goal was not to treat or prevent a hereditary disease, but to try to give it a feature inherent in a small number of people: the ability to resist an infection with HIV, the virus that caused AIDS in the future.
They stated that the parents in question refused to identify or negotiate, and would not show where they lived or where the work was carried out.

Not verified by science yet

No one has independently substantiated his claim and has not been published in a journal to be reviewed by other experts. In an interview in Hong Kong on Monday, he participated in one of the organizers of an international conference on genetic editing, which began on Tuesday, and previously had exclusive interviews with the Associated Press.
"I'm not only about doing something for the first time, but I also feel a strong responsibility to identify the example," he told AP. & # 39; & # 39; To decide what to do & # 39; & # 39; society.

More than 120 Chinese scientists condemned He Jiankui's explanation of the release of two genetically modified babies to prevent HIV transmission; in an open letter, they stated that experimenting with people was "crazy" and had serious potential consequences.
The text was signed by scientists from various institutions such as Tsinghua, Beijing and Fudan and Chinese Academy of Science universities.
"The irreversible transformations of human genetic material, which are extremely vague in science, will inevitably become involved in the human genetic group," the DPA quoted the letter as saying.
"It is possible that newborns are healthy for a while, but the risks and potential damages to the human group Araştırma are incalculable," the researchers said.
They also asked that the experiments were dav a serious blow to the global reputation of Chinese science anda and that the authorities should act as soon as possible and conduct the investigation of the case.
. Pandora's box has been opened and we may be able to close it before the damage can be compensated, "he warned.

However, George Church from Harvard University, a famous geneticist, advocated an attempt at genetic regulation for HIV, which he described as a sağ growing and important threat to public health Ancak.
"I think he's right," Church said.
In recent years scientists have discovered a relatively simple way to regulate genes, DNA strands that govern the body. The tool called CRISPR-cas9 allows DNA operations to provide a required gene or to disable one that causes problems.

Jennifer Doudna

One of the discovery of the CRISPR-Cas9 gene editing technique, American Jennifer Doudna also criticized in his statement.
"If confirmed, this study is breaking with the measures and transparent approach of the implementation of the CRISPR-Cas9 global scientific community," said Doudna, professor of Chemistry and Molecular and Cell Biology at the University of California at Berkeley.

Doudna said the study has not been published or peer-reviewed by the scientific community.
The researcher also attends the Human Genomic Printing Summit, which he thinks will join Hong Kong.
If a scientific analysis confirms this study, it will confirm that embr there is an urgent need for scenarios where there is a clear medical need that does not need to include the use of genetic regulation in human embryos, and where another therapeutic approach is not appropriate Bilimsel.
The mechanism of CRISPR-Cas9 has been known for nearly thirty years, and in 2003, Spanish microbiologist Francisco Martínez Mojica discovered that microorganisms are what they use to defend themselves, to cut genetic material from viruses, and to incorporate that material into their own DNA.
Mojica's discovery suggested that a few years later, Doudna and French researcher Emmanuelle Charpentier could artificially reproduce the system and change the genome exactly in humans in 2012.


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